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Kenazole (Ketoconazole)

Kenazole works by interfering with the structure of the fungal cell wall. Depending on the fungus and depending on the dose used, Kenazole may kill the fungus or just inhibit its ability to reproduce. Fungal infections for which Kenazole is commonly used include: Malassezia dermatitis, Aspergillosis, Cryptococcosis, Coccidioidomycosis (Valley fever), Histoplasmosis, Blastomycosis, Dermatophytosis (ringworm). There is another effect of Kenazole that is generally thought of as a side effect but that can be used as a therapeutic goal. Kenazole blocks the synthesis of cortisone in the adrenal gland. This means that Kenazole can be used to treat Cushing's disease, in which an excessive amount of adrenal hormone is produced. Kenazole can also be used to slow the body's removal of the immunomodulating drug cyclosporine. Cyclosporine is a very expensive medication so using Kenazole to spare its use may reduce the dose requirement enough to make treatment affordable.

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