Perative works by interfering with the structure of the fungal cell wall. Depending on the fungus and depending on the dose used, Perative may kill the fungus or just inhibit its ability to reproduce. Fungal infections for which Perative is commonly used include: Malassezia dermatitis, Aspergillosis, Cryptococcosis, Coccidioidomycosis (Valley fever), Histoplasmosis, Blastomycosis, Dermatophytosis (ringworm). There is another effect of Perative that is generally thought of as a side effect but that can be used as a therapeutic goal. Perative blocks the synthesis of cortisone in the adrenal gland. This means that Perative can be used to treat Cushing's disease, in which an excessive amount of adrenal hormone is produced. Perative can also be used to slow the body's removal of the immunomodulating drug cyclosporine. Cyclosporine is a very expensive medication so using Perative to spare its use may reduce the dose requirement enough to make treatment affordable.
Other names for this medication:
Ketoconazole,
Nizoral,
Akorazol,
Arcolan,
Arcolane,
Asquam,
Biogel,
Clarazole,
Conazol,
Daktagold,
Daktarin,
Dezor,
Diazon,
Dikoven,
Eumicel,
Extina,
Funginoc,
Fungoral,
Ilgem,
Kenazol,
Kenazole,
Ketazol,
Ketokonazol,
Ketolef,
Ketovid,
Ketozal,
Liondox,
Lizovag,
Micoral,
Micosin,
Muzoral,
Mycoderm,
Noell,
Orifungal,
Oronazol,
Panfungol,
Perative,
Phytoral,
Pristinex,
Tiniazol,
Tinuvin,
Xolegel,
Yucomy,
Zoloral,
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