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Prosteride is a synthetic 4-azasteroid compound. Prosteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation.

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trained researchers assessed participants using the Standardised Mini Mental State Examination, Delirium Rating Scale-Revised 98 and Informant Questionnaire on Cognitive Decline in the Elderly, informing ultimate expert diagnosis using Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria for dementia and delirium (reference standards). Physicochemical properties of a high molecular weight levan from Brenneria sp.

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We report the results of a MRI and clinical study that confirm the efficacy of this approach. Anticoagulant and FGF/FGFR signal activating activities of the heparinoid propylene glycol alginate sodium sulfate and its oligosaccharides. In addition, application of these techniques should, for the first time, permit the immunological distinction of these T6-positive mononuclear cells from other cells bearing Ia antigens, such as dermal histiocytes and certain lymphocytes, in normal and diseased skin. Both the causes and the magnetic-resonance semiotics of the obstructive damages of brachyocephal veins and of the cerebral venous sinuses were described.

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To illuminate the nature of the lived experiences of nurse practitioners (NPs) interacting with patients, to discover the essential meanings of those lived experiences, and to articulate a structure gleaned from the essential meanings. Techniques integrating gene expression profiles and biological networks for the identification of network-based disease biomarkers are receiving increasing interest.

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The rates of compound I formation at 4 degrees C are 8.0 x 10(4), 1.3 x 10(6), and 1.6 x 10(3) M-1 s-1 for the R38A, R38H, and R38H/H42V mutants, respectively. Mistletoe in conventional oncological practice: exemplary cases.

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Expression of apolipoprotein A-I in porcine brain endothelium in vitro. To illustrate the contemporaneity of applications, an analysis of specialized papers published in the last six years has been made. A subgroup of malignant otitis externa may exist that is not as susceptible to parenteral antibiotics and local debridement.

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This prospective observational study included a total of 540 incident patients who started PD at NHIC Ilsan Hospital, Korea from January 2000 to December 2009. Measuring the effect of ion substitutions on the reversal potential of the receptors and applying the Goldman-Hodgkin-Katz constant field equation indicates the receptors are at least as permeable to calcium as to sodium.

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The particle size of Ch-HPC nanogels was reversibly controlled by the temperature and salting-out effect. 24-hour ambulatory blood pressure was measured with an ambulatory monitor using an oscillometric method. No human mutations have yet been described in the other related receptor gene, c-erbA alpha. We investigated the associations of meat intake and the interaction of meat with genotype on fasting glucose and insulin concentrations in Caucasians free of diabetes mellitus.

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Comparisons with the orthologous gene clusters of the Australian Cylindrospermopsis raciborskii strains AWT205 and CS505 and the partial gene cluster of the Israeli Aphanizomenon ovalisporum strain ILC-146 revealed a high gene sequence similarity, but also extensive rearrangements of gene order. Attempts to generate a pbp1a pbp2a double-disruption mutant failed. When platelet aggregation was measured during the first 6 hours of the oedema formation, the lag time between the addition of collagen and the beginning of the aggregation was increased. Laparoscopic surgery has become increasing popular, and its use has been proven safe.

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Burden of tuberculosis in Xinjiang between 2011 and 2015: A surveillance data-based study. Invertebrates either showed no clear spatial patterns in MeHg concentrations (blue crabs, fiddler crabs) or increasing concentrations further downstream (grass shrimp). Activated charcoal in barbiturate and glutethimide poisoning of the dog. There were also seemingly different patterns by asthma status, in that subjects without asthma had more marked decreases in FEV1, TLC, RV, and FRC than subjects with asthma. It is expressed ubiquitously, with high and constitutive expression in muscular tissues.

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The produced PHSN were applied as a carrier to study the controlled release behaviors of Brilliant Blue F (BB), which was used as a model drug. Hepatitis B is transmitted by three main routes: contact with blood and body fluids, sexual contacts, and perinatally from the infected mother to her newborn baby. patens genome, it became clear that it encodes many core proteins important for auxin homeostasis, perception, and signalling, which have also been identified in flowering plants. Zipeprol (Zinolta) abuse among American adolescents in Korea: a discussion of the problem, clinical presentation, and treatment.

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Long exposure of cells to NO results in an irreversible inhibition of cellular respiration not dependent on a generalized superoxide or peroxynitrite formation. Spontaneous and intentional pattern switching in a multisegmental bimanual coordination task. In this article, we review the discovery of the FGF23 protein, as well as its biochemistry, localization of production, receptor specificity and mechanisms of action. This study evaluated the cardiometabolic, behavioral, and psychosocial factors associated with weight status among hospital employees. Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy.

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Several studies focusing on octogenarian patients concluded that a complete removable denture retained by a single symphyseal implant is a simple, efficient and cost-effective option. The aim of this study is to equalize the influence of age-related changes and to test the hypothesis that specific structural brain changes are mediating the development of unique clinical features in late-onset paranoid psychosis (LOPP). Development and characterization of biodegradable nanocomposite injectables for orthopaedic applications based on polyphosphazenes.

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KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway. Thus trophoblast appears to express a GPI-anchored Fc gamma receptor III in first trimester but not term placentae. Furthermore, although TNF-induced proteolytic activation of procaspase-8 was completely inhibited by Z-VAD-fmk or Z-DEVD-fmk, the partial proteolysis of procaspase-8 to the p43/41 intermediate and p18 active fragment was detected in the presence of Z-Asp-CH2-DCB. We have found that microRNA-21 (miR-21) is a novel target gene for Bcl6 in Treg cells.

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The results of the first trial to look exclusively at the elderly--the Prospective Study of Pravastatin in the Elderly at Risk--have added enormously to our understanding of the use of statins in the elderly. We compared the cost-effectiveness of two different strategies for the second dose of Measles Containing Vaccine (MCV) to one dose of MCV through routine immunization services over a 15-year time period for a hypothetical birth cohort of 3 million children. IRBP mRNA expression was examined using RT-PCR and in situ hybridization. Effects of changes in pH and CO2 on pulmonary arterial wall tension are not endothelium dependent.

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Trends in pathology and long-term outcomes after resection of colorectal cancer: 1971-2013. Early recognition of MPS is important as it enables prompt implementation of enzyme replacement therapy (ERT).

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We recommend that resuscitation in utero by intrauterine transfusion should be considered before the 33rd week of gestation in cases of severe fetal anemia. Spherical beads constitute fine structures of the observed complexes even when they appear as aggregates. Evidence is presented to demonstrate that the composition of metabolites in the striatum is altered, primarily in the form of an elevated level of lactate, in human neonates who have suffered various perinatal disorders, such as germinal matrix hemorrhage, intrauterine growth retardation, and asphyxia. Measuring the effects of an international health professions faculty development fellowship: the FAIMER Institute. A patient who received postoperative radiation therapy for the treatment of a chromophobe adenoma developed a fibrosarcoma of the pituitary gland region 10 years later.

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Studies in developing animals have shown that anesthetic agents can lead to neuronal cell death and learning disabilities when administered early in life. Limited proteolysis by Staphylococcus aureus V8 protease as well as supershift assays using antibodies against c-Fos and c-Jun proteins demonstrated the possible difference in constructive partner proteins of activator protein-1 among nuclear extracts of the CA1 subfield obtained from gerbils with single, tolerated and repeated ischemia.

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Motor activity of 14 rats (12 neuroma, 2 sham), measured using a stabilimeter, was compared on a weekly basis to autotomy scores for a total of 7 weeks after surgery. Achieving selective and sensitive carbohydrate-protein interactions (CPIs) using nanotechnology is an intriguing area of research. TOPPER: topology prediction of transmembrane protein based on evidential reasoning.

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