Tenvir disoproxil fumarate (TDF) was approved by the FDA in 2001 for use in combination with other antiretroviral agents in adults with HIV infection. This recommendation was based primarily on a randomized, placebo-controlled Phase 3 study of HIV treatment-experienced individuals with detectable viral load on stable combination antiretroviral therapy. The addition of TDF to the existing regimen resulted in a significant decrease in viral load at week 24 of the study (0.61 log10 average decrease in viral load from baseline, compared with 0.03 log10 decrease in the placebo group; p < .0001). An increase in CD4 count of 12.6 cells/µL was seen in the TDF group, compared with a decrease of 10.6 cells/µL in the placebo group (p = .0008).(1) In 2012, FDA approval was extended to pediatric patients 2 years of age and older. Also in 2012, the FDA approved the combination of TDF and emtricitabine for use as preexposure prophylaxis by HIV-uninfected adults at high risk of sexually acquired infection with HIV.
Other names for this medication:
Tenofovir,
Atripla,
Tenvir,
Trioday,
Truvada,
Viraday,
Viread,
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Wymox,
Topirol,
Amolin,
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Clavamel,
Sinalfa,
Controloc,
Dresplan,
Actinum,
Sofovir,
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Antiox,
Maxpro,
Fubenzon,
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