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Trileptal (Oxcarbazepine)
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Oxcarbazepine

Trileptal is a homologue of the well-known antiepileptic drug carbamazepine. It was developed as an alternative to carbamazepine for patients who had adverse reaction to carbamazepine or diphenylhydantoin. Despite its structural similarities, Trileptal differs from carbamazepine in pharmacokinetic behavior, biotransformation profile, and interaction potential. Trileptal is like carbamazepine in its mechanisms of action and antiepileptic efficacy but has better tolerability and fewer interactions with other drugs. Most of the clinical development took place during the early 1990s, when it received approval in several countries. It was approved by the FDA in 1999. In 2003, the FDA approved Trileptal as a monotherapy in children 4 years or older with partial epilepsy. This was the first epilepsy medication in 25 years to be approved for use as monotherapy in children.

Other names for this medication:
Oxcarbazepine, Trileptal, Actinum, Apydan, Auram, Aurene, Deprectal, Leptal, Oxcarbazepin, Oxcarbazepina, Oxetol, Oxicodal, Tolep,

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Cordyceps militaris has been used in traditional Chinese medicine for many years, but its frequent degeneration during continuous maintenance in culture can lead to substantial commercial losses. Secondary hyperparathyroidism (2 degrees HPT) is a consistent finding in renal failure. Hepatitis C virus infection and lichen planus: a systematic review with meta-analysis. Epidemiological distribution of HIV infection among pregnant women in the ten regions of Cameroon and strategic implications for prevention programs

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To compare postoperative dosimetry and acute toxicity of new 0.5-mm (125)I seeds in 20-gauge (20G) diameter prostate brachytherapy (PB) needles with standard 0.8-mm seeds in 18G needles. Cell biological changes of Purkinje neurons following indirect cerebellar injury were analyzed by immunohistochemistry. Engagement of parents/guardians of children with SCD in identifying barriers and facilitators to clinical trial enrollment may be critical to the development of strategies to enhance SCD trial completion.

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Treacherous Pavements: Paving Slab Patterns Modify Intended Walking Directions. The freeze-cleave technique demonstrates the presence of gap junctions at early stages of mouse cardiac muscle ontogenesis.

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A design of a microwave noninvasive continuous blood glucose monitoring sensor and its interference test results are presented. Hepatic branched-chain alpha-keto acid dehydrogenase complex in female rats: activation by exercise and starvation. Research tools different from randomized controlled trials, focusing on the heterogeneity of patients rather than the intervention per se, are required to develop this concept further. Six patients with open-angle glaucoma and acquired pit-like changes in the optic nerve head are presented.

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Cognitive behavioral treatment of obsessive compulsive disorder: a broader framework. Snail-Induced Epithelial-to-Mesenchymal Transition Enhances P-gp-Mediated Multidrug Resistance in HCC827 Cells. We compare the results with monatomic water (mW), ELBA, and direct iterative Boltzmann inversion of SPC/E. An increasing number of PTCL-specific retrospective analyses have been reported, and the first data from PTCL-restricted prospective clinical trials have appeared more recently.

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Bacterial microbiomes of individual ectomycorrhizal Pinus sylvestris roots are shaped by soil horizon and differentially sensitive to nitrogen addition. However, the inter-group difference was statistically insignificant.

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At least three hemagglutinins and five proteinases are produced to satisfy these requirements. Findings showed a large left ventricular pseudoaneurysm, which was subsequently confirmed by left ventriculogram. The compression isotherms show that the removal of the core leads to an increase of the surface pressure at low compression, and the same effect can be observed when the polymer cross-link density is decreased. Nonenzymatic glucosylation of lens proteins in different types of cataracts.

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Nutrient deprivation is a likely contributor to intervertebral disc (IVD) degeneration. TPN729MA is a novel selective PDE5 inhibitor currently under clinical development in China for the treatment of erectile dysfunction.

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The indirect use of CT numbers to establish material properties needed for Monte Carlo calculation of dose distributions in patients. Echocardiographic diagnosis of partial pericardial constriction of the left ventricle. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptibility to AS in the Chinese population. Foot-and-mouth disease is a highly contagious disease of cloven hooved animals.

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Bilateral anterior tibial compartment syndrome in association with hypothyroidism. Diflunisal, Azapropazone and Indomethacin caused an increase and Piroxicam a decrease in the uric acid excretion. From clinical findings, the subcutaneous emphysema was thought to be caused by surgical rather than anesthetic factors. Religious belief can be defined as a commitment to an ultimate meaning in life. Complex atrial anatomy continues to challenge transcatheter device closure of septal defects.

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If vasospasm is resistant to conservative measures, balloon angioplasty or intra-arterial papaverine therapy should also be considered. This paper is number 2 in a series developed through a partnership between ISIMM and NordiQC for the purpose of reporting research assessing the performance characteristics of immunoassays in an external proficiency testing program.

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We present an approach to using surveillance data to help guide application of AAP recommendations for immunoprophylaxis to local patterns of RSV outbreaks. However, epidemiological studies on the relation between SHSe and dental caries are limited and have yielded inconsistent results. The ETN provides sufficient stability of diaphyseal tibial fractures including those involving the metaphysis. Facilitating factors included the established professional degree and association, continuing professional development requirements, a core group of active professionals and an existing foundation from other projects. Photodegradation can be a major route of dissipation for pesticides applied to shallow rice field water, leading to diminished persistence and reducing the risk of offsite transport.

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Early seizure onset in intractable frontal lobe epilepsy is associated with IEDs discordant with seizure focus. Metabolic Profile of Isocorynoxeine in Rats Obtained by Ultra-High Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry. This work explores the transient effects of overexpressing ORCA3 under the control of a glucocorticoid-inducible promoter system in C.

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Effect of topical steroids on nasal nitric oxide production in children with perennial allergic rhinitis: a pilot study. To elucidate the function of lysine-rich histone, yeast cells, which are believed to lack this histone, were transformed with an expression vector carrying the sea urchin histone H1 gene under control of an inducible promoter. The odds ratio for inheriting defective SIAE alleles was 8.6 in all autoimmune subjects, 8.3 in subjects with rheumatoid arthritis, and 7.9 in subjects with type I diabetes.

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Flashing lights (photopsia) and floaters are common visual phenomena and patients frequently present to hospital with these symptoms. Acid phosphatase levels in bone marrow: value in detecting early bone metastasis from carcinoma of the prostate. The process by which human fingers gives rise to stable contacts with smooth, hard objects is surprisingly slow. Evaluation of heparin dosing based on adjusted body weight in obese patients. We present a new design for spectral-domain optical coherence tomography that allows balanced detection using a single camera.

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Bacillus weihenstephanensis characteristics are present in Bacillus cereus and Bacillus mycoides strains. Absorption and fluorescence spectra of hypericin sodium salt in complexes with albumins

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Fractions and transformation of organic phosphorus in sediments from a eutrophic lake in China. Further studies that focus on the underlying reasons for this difference are needed to address these disparities. After 22h of intensive care, the patient had made a complete recovery. There is a wide geographical variation in asthma prevalence and one explanation may be in dietary salt consumption. Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo.

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The growth of stem cells in in vitro conditions requires optimal balance between signals mediating cell survival, proliferation, and self-renewal. Laparoscopic inguinal hernia inversion and ligation in female children: a review of 173 consecutive cases at a single institution.

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Novel manganese oxide particles with complex morphologies and different nanostructures (i.e., spherical/lamellar) were synthesized by initial preparation of a coordination complex of manganese with 1,4,7,10-tetraazacyclododecane (cyclen), followed by characterization of the nanostructured oxide as a catalytic material for ethanol oxidation. The furan aldehydes hydroxymethylfurfural (HMF) and furfural have received increasing attention recently. Our data demonstrate heterogeneity of nicotine deliveries both between products and also with the same products used by different cohorts, eg, accustomed users versus smokers. Retinoic acid represses the gene expression of topoisomerase II in HEP3B cells. Short-term hyperglycemia protects axons against TNF-induced optic nerve degeneration.

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Management of concussion necessitates coordinated care by the members of the sports medicine team due to its pathophysiology and complexity of management during recovery. Metabonomics-based study of clinical urine samples in suboptimal health with different syndromes. Efficiency analysis is necessary in order to avoid waste of materials, energy, effort, money, and time during scientific research. Oral history methodology is used to collect information on the life experiences of six female elders (kupuna) to identify life themes and cultural values and, more important, to contribute to cultural preservation. It is widely recognized by research peer groups for conducting valid tests.

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J ileal pouch-anal anastomosis for chronic ulcerative colitis: complications and long-term outcome in 1310 patients. The symptom of stress incontinence was present in 71 patients, and was verified in 56. Oocytes in the experimental group were vitrified by Cryotop using vitrification medium (Origio, Denmark) and kept in liquid nitrogen for one month.

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Within EC afferent input and short-term synaptic plasticity from lateral entorhinal cortex, considered to convey contextual information to the hippocampus was increased. The Effects of Aging and Dual Tasking on Human Gait Complexity During Treadmill Walking: A Comparative Study Using Quantized Dynamical Entropy and Sample Entropy. Importantly, stromal cell-mediated resistance to targeted inhibition of oncogenic FLT3 kinase activity by quizartinib was circumvented by 6PGD knockdown.

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Single nucleotide polymorphisms in the CD40 gene associate with the disease susceptibility and severity in knee osteoarthritis in the Chinese Han population: a case-control study. This noninvasive method can specify the extent and the intensity of an acute attack in patients with previously known ulcerative colitis. A full-thickness burn was induced in the abdominal skin of rats, followed by injection of Evans blue dye. Cytokine gene polymorphisms and breast cancer susceptibility and prognosis. IGF-II stimulation of in vitro maturation, in vitro fertilisation and subsequent development of buffalo (Bubalus bubalis) oocytes in vitro.

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