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Valacyclovir
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Valacyclovir

Valacyclovir is an L-valyl ester of acyclovir that is converted to acyclovir after oral administration by first-pass intestinal and hepatic metabolism (Medical Letter 1996). Acyclovir targets a viral enzyme, thymidine kinase which inhibits DNA chain elongation. Acyclovir is activated intracellularly by the viral thymidine kinase to the monophosphate derivative, which is then converted by the cellular enzymes to the diphosphate and then to the triphosphate analog, which inhibits viral DNA polymerase (O'Brien and Campoli-Richards (1989)). Valacyclovir achieves a 3–5 fold higher plasma levels than acyclovir resulting in higher bioavailability and less frequent dosing. Valacyclovir produces a more rapid resolution of zoster-associated pain and a shorter duration of post-herpetic neuralgia (Beutner et al., 1995). It is used for prophylaxis therapy to reduce the risk of cytomegalovirus (CMV) disease in transplant recipients (Lowance et al., 1999). Valtrex is the hydrochloride salt of Valacyclovir and is offered in 250 mg, 500 mg, and 1 g tablets, primarily indicated for the treatment of HSV and VZV infections (Sweetman (2005)).

Other names for this medication:
Valacyclovir, Valtrex, Bagovir, Herclov, Rapivir, Talavir, Vadiral, Valaciclovir, Valavir, Valcivir, Valvir, Valvirex, Viranet, Zelitrex,

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The role of platelet reactivity assessment in dual antiplatelet prophylaxis after transcatheter aortic valve implantation. Three methods of estimating group and individual dietary consumption have been developed and assessed in a case-control study of diet and breast cancer.

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Such data supports the notion of clinical staging, and the tailored implementation of treatments according to the stage of illness. Mechanisms of Glucocorticoid-receptor-mediated Repression of Gene Expression. Factors associated with successful AVM radiosurgery in this population are examined, and comparisons with outcomes in adult patients are reviewed. This long-term follow-up study indicates, that primary OT is a progressive disorder. Consequently, the level of acetyl H3 binding to MCP-1 promoters was increased in CD36-deficient hepatocytes, causing hepatic-specific MCP-1 transcriptional activation.

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The kinetics of formation and hydrolysis of the gamma-glutamyl thioester intermediate during CPS catalyzed hydrolysis of glutamine were determined. Whereas pairwise causal influences between elements can be quantified with existing methods, quantifying multiple influences among many elements poses two major mathematical difficulties. Reliable methods might have a promising perspective insofar as they would in principle allow the prediction of parameters for a wide range of sorbents.

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Ten patients with stage I-III NSCLC underwent an rCT immediately followed by a planning PET/CT scan, both carried out with arms placed above the head and immobilisation in the treatment position. In a qualitative evaluation of continuous distribution through the ANC and EPI, semi-structured, individual and group interviews were conducted in Kenya, Malawi, Mali, and Rwanda. We propose a novel interactive visualization framework which utilizes this metric to extract, organize and visualize features of varying density and complexity hidden in large numbers of streamlines.

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MiRNAs were found deregulated (upregulated or downregulated) and implicated in cancer development with various roles which depend on their gene target. In this review, we highlight the single molecule techniques that can be used to assess the effect of point mutations on beta-cardiac myosin function. The larval electric organ of Pollimyrus isidori consists of four longitudinal tubes, a dorsal and a ventral pair, which begin behind the skull, end at the beginning of the caudal peduncle and show myotomic segmentation.

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Generation of high-performance binding proteins for peptide motifs by affinity clamping. Up-regulated expression of CBP in Jurkat cells could reduce cell homogeneity and promote cell apoptosis. EEG results revealed that segmentation-related responses precede category-selective responses.

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The relationship between opiate substitution treatment and reincarceration deserves to be studied further on larger samples in order to better evaluate its impact on social rehabilitation of drug addicts. Metabolic stress responses in Drosophila are modulated by brain neurosecretory cells that produce multiple neuropeptides. COI is characterized by an overall enhancement of noradrenergic tone at rest and by a blunted postganglionic sympathetic response to standing, with a compensatory cardiac sympathetic overactivity. It is essential to investigate the current quality of healthcare before implementing any interventions.

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SPRM maps the refractive index (RI) of single LiCoO2 nanoparticles, which significantly decreases with the gradual extraction of Li-ions, enabling the optical read-out of single nanoparticle electrochemistry. hydrophila by blocking the citric acid cycle through inhibition of aconitase.

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These findings support the use of liraglutide as an effective GLP-1 agent to add to metformin. Radiation-associated risk was assessed using Poisson regression and included adjustment for several demographic, lifestyle, host and sun exposure factors.

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This study aims to conduct an international comparison of the proportions of tweets about HPV vaccines that express concerns, the types of concerns expressed and the social connections among users posting about HPV vaccines in Australia, Canada and the UK. Moreover, no significant differences were observed regarding either patient characteristics or hemodynamic parameters between the two groups. A practical and comprehensive approach to glucose management in the ICU will be outlined, touching upon important issues such as glucose variability, target population, and hypoglycemia. Proton MR spectroscopy in infants with cerebral energy deficiency due to hypoxia and metabolic disorders.

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A half-battery cell composed of the thermally-cured radical network coatings displayed a rapid, reversible, and almost stoichiometric redox-activity even with a thickness of ca. To report a single-institutional experience using intensity-modulated radiotherapy with daily image-guided radiotherapy for the reirradiation of recurrent and second cancers of the head and neck. The nephrotoxicity of cyclosporin (CsA) continues to be a clinical problem that detracts from its obvious benefits as an immunosuppressive agent.

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Changes in direct current (DC) potentials and infra-slow EEG oscillations at the onset of the luteinizing hormone (LH) pulse. Concentrations and vertical profiles of various fractions of airborne particulate matter (suspended particulate matter (SPM), PM10 and PM2.5) have been measured over the first three metres from ground in a street canyon. Thus, we conclude that the abnormal growth of the dnl4 mutant strain is a synthetic phenotype resulting from Dnl4 deficiency in combination with undetermined genetic factors in the M1-2B strain background.

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Baseline demographic characteristics, clinical, radiologic and endoscopic findings were collected. Intermolecular nuclear shielding due to the aromatic amino acids of proteins and to porphyrins. Exstrophy of the bladder is a spectrum of congenital anomalies that involve the structures of the lower abdominal wall.

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Aim of the study was to evaluate its early clinical and hemodynamic performances in a multicenter regional registry. We investigated the contribution of three structural elements of the substrate- binding cavity of the Escherichia coli homologue, DnaK, to substrate specificity by investigating mutant DnaK proteins for binding to cellulose-bound peptides. Novel collagen sponge reinforced with polyglycolic acid fiber produces robust, normal hair in murine hair reconstitution model. A significant difference in air-bone gaps (frequencies, 0.5, 1.0, and 2.0 kHz) lasting at least eight weeks was found between the ears treated with SF6 and the air-treated ears.

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Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. The use of this technique for studying potential laser-induced disturbances was also demonstrated. We found the combination of PFR was the most effective in HGFs, whereas, RFT was the most effective combination in HPDL fibroblast.

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In contrast, pretreatment of DOI, but not quinpirole, attenuated the acute effect of clozapine. With the view of identifying the mutants, we aim at analyzing short deep sequencing data called reads. Long-term functional results after pharyngoesophageal reconstruction with the radial forearm free flap.

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falciparum, who had a chloroquine (CQ) response failure, were collected pre-treatment. A new radiologic classification based on computed tomography (CT) is presented, its application illustrated, and its accuracy documented. Synergistic interactions of combinations of topotecan with standard drugs in primary cultures of human tumor cells from patients.

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Lactate significantly increased in CM compared with non-conditioned myoblasts. We demonstrate that mosaic eyes function is required within the retinal pigmented epithelium, rather than in dividing retinal cells. Secondary metabolite gene clusters are often located subtelomerically and recently it has been shown that proteins involved in chromatin remodeling, such as LaeA, ClrD, CclA, and HepA mediate cluster regulation.

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Endoscopic endonasal transsphenoidal surgery for patients aged over 80 years with pituitary adenomas: Surgical and follow-up results. In this review we analyze molecular structure and mechanisms of regulation of two closely-related transcription factors SNAI1 and SNAI2, which play an important role in induction and progression of epithelial-mesenchymal transition during both normal development and carcinogenesis. Central core disease (CCD) is a well recognized, relatively mild, non- or slowly progressive, dominantly inherited, congenital myopathy due, at least in some families, to mutations in the ryanodine receptor gene on chromosome 19q13.1. The present study identified additional territory infarction as a significant predictor of early in-hospital death. Major advances in radiotherapy techniques, increasing knowledge of tumour biology and the ability to translate these advances into new therapeutic approaches are important goals towards more individualized cancer treatment.

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The transcriptional activity of the leucine zipper structure of TSC-22 is greater than that of the full-length TSC-22. The huge burden of malaria in developing countries urgently demands the development of novel approaches to fight this deadly disease. Further research is needed to identify the highly selected subset of patients who may benefit from local treatment of the primary tumor and/or metastatic disease.

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This study provides Class IV evidence that for patients with epilepsy, engaging in an online patient community improves self-management and self-efficacy. The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint? We conducted a descriptive, retrospective and analytic survey carried on 77 subjects having been followed in the child psychiatry department of Sfax for depressive disorders diagnosed according to the DSM-IV TR criteria during a period of 9 years (from January 1st 1998 till 31st December 2006)

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Due to possible falsification of sugar cane products with cheaper alternative (sugar beet) on the market, a simple analytical methodology needs to be developed to control the authenticity of sugar products. Such an understanding will only emerge after new data are placed in the context of the wealth of physiological data on which they are founded. Metronomic reloaded: Theoretical models bringing chemotherapy into the era of precision medicine. Descriptions of the organisation of health care in different countries can be found, but no studies have specifically compared the legal and formal organisational systems in Sweden and China.

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The frequency of such events was rare, 1.7 x 10(-5) in integrative vector and 2 x 10(-3) in the case of replicative vector. Far more attention to this aspect is needed if findings in this field are to be accepted as valid and useful. Selenium depletion in patients with gastrointestinal diseases: are there any predictive factors? Effect of neuroactive aminoacids on central mechanisms of vascular regulation Prevalence rates were high and the clinical impact needs to be further investigated.

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Regional program for bone allograft harvesting following multiorgan procurement in Pomeranian Academy of Medicine in Szczecin. A review of the literature does not currently establish the value of a pleurectomy in cases of a homolateral effusion in bronchial carcinoma.

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The results provide a working framework within which the dynamics of information storage in hippocampal and prefrontal cortical networks is profiled. This paper reviews recent progress in the development of synthesis-gas fermentations, with emphasis on efforts to increase the efficiency of gas mass transfer. Although the mean volume of oedema was similar for cystic and noncystic tumours, the ratio of oedema to tumour volume was approximately four times as high in cystic supratentorial tumours. Actin cytoskeleton in plants: from transport networks to signaling networks. Surgical logbooks of two senior trainees were reviewed over a 2-year period.

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The biological behavior of cardiac sarcomas is similar to all soft-tissue sarcomas. Dermoid cysts are rare congenital lesions derived from pluripotential cells. A comparison was made based on voice disorders and responses to treatment between patients who received psychotherapy and patients who did not. However, the Bonferroni correction may be too conservative given the strong linkage disequilibrium among some of the markers and our aim to replicate the earlier published findings.

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The overall guarded prognosis is similar for fetuses with Dandy-Walker malformations for whom IVA or CVA has been sonographically diagnosed. We demonstrate a position-dependent error in quantitation and propose a correction method by measuring water signals. Because Gr63a is expressed in a well-defined population of neurons, future work may now be directed at dissecting more complex neurosensory and neuroendocrine circuits that modulate aging in Drosophila. Blood urea nitrogen, serum cystatin C levels, duration of chronic kidney disease, and the duration of hemodialysis were compared between the chronic kidney disease patients and end-stage renal disease patients undergoing hemodialysis.

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Most individuals should be able to achieve these physical activity goals and thus attain a cardiorespiratory fitness level sufficient to result in substantial health benefits. To investigate the longitudinal relationship between pain interference and incident general medical conditions in a nationally representative sample.

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The initial clinical picture of NF mimics that of cellulitis or erysipelas, including fever, pain, tenderness, swelling and erythema. The hydrolytical degradation studies indicate that PU-glycidyl systems (PUg1 and PUg3) can be degraded in 20 mM HEPES buffer at pH 7.4 in approximately 8 h but that PU1 and PU3 lasted much longer. To test the hypothesis that annual hospital severe sepsis case volume is associated with mortality during admissions with severe sepsis in teaching and nonteaching hospitals. For this purpose, BMI1 was silenced in 2 PC cell lines (LNCaP and DU 145). Neuromuscular disorders in children are a heterogeneous group of conditions with a variable age of presentation and overlapping clinical manifestations, many of which have progressive respiratory morbidity.

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Structure and assembly of the Alu domain of the mammalian signal recognition particle. These unusual PET findings may indicate the presence of pathological changes not yet identified. Bisoprolol also abolished the reduction of the beta1-adrenergic receptor expression caused by longer-term incubation with isoproterenol and the autoantibodies. The influence of thylakoid lipids on the association kinetics and thermal stability of the major light-harvesting complex of photosytem II (LHCII) has been studied in vitro. Our findings also show that various mitochondrial enzymes exhibit different susceptibilities and reversibilities to pathological stress.

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Trace-Level Volatile Quantitation by Direct Analysis in Real Time Mass Spectrometry following Headspace Extraction: Optimization and Validation in Grapes. Therefore, an overview of methods to mitigate artifacts in OCT imaging of the skin is of paramount importance.

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The influence of subacute benzene intoxication on the submicroscopic structure of liver cells. The AUC for UF-Pt on day 5 showed the best correlation with percentage reduction in leukocyte count and in absolute neutrophil count. Tumour growth and EGFR expression levels are also decreased by HT treatment in HT-29 xenograft. Infection in the TNFR-/- mice was exacerbated, although in the Brucella-infected mice splenomegaly, the main indicator of immunopathology, was reduced. In the non-ENU groups, the mean MF was slightly but not significantly higher in the PH group than in the non-PH group.

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Disclination mediated dynamic recrystallization in metals at low temperature. Mannose receptor is present in a functional state in rat microglial cells. Prospective study of mortality in relation to alcohol drinking habits in 1978, with causes of death sought over the next 13 years (to 1991). A weak germ-line excision mutation blocks developmentally controlled amplification of the rDNA minichromosome of Tetrahymena thermophila. Unwanted pregnancy by itself was significantly related to adult offspring schizophrenia-spectrum disorders in both the total sample and the HR subgroup, but the effect was found to be limited to the HR group and occurred in interaction with genetic risk.

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The audit highlighted areas for improvement, which have been addressed. JAK/STAT signal transduction: Promising attractive targets for immune, inflammatory and hematopoietic diseases. Coupling a nucleotide-dependent oligomerization cycle to the disassembly of a target protein complex may be a general feature of ATP-hydrolyzing AAA domains. LATE-ONSET SELF-HEALING LANGERHANS CELL HISTIOCYTOSIS: REPORT OF A VERY RARE ENTITY. Susceptibility values in DN on QSM and DN-to-cerebellum signal intensity ratios on unenhanced T1 -weighted images (T1 ratios) on 3T were analyzed.

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Azacitidine in the treatment of older patients affected by acute myeloid leukemia: A report by the Rete Ematologica Pugliese (REP). We describe the clinical outcomes of those samples identified with these subchromosomal events. Engaging Adults With Chronic Disease in Online Depressive Symptom Self-Management. The phenotypic consequences of tumour suppressor gene mutations in mice and humans show parallels and contrasts, and both can contribute to the elucidation of disease processes. The results indicate a slight reduction in the ethnobotanical and medical knowledge in this area, when compared with neighboring regions.

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Low prevalence of Helicobacter pylori in inflammatory bowel disease: association with sulphasalazine. The commonly reported association of AKR1B1 with DR may be due to an association of the gene with younger age at onset of diabetes. These findings suggest that benign glands on surgical margins are an unusual cause of postoperative detectable PSA. Extraction of DNA from 14 fertile samples was achieved followed by molecular studies on two mitochondrial genes (nad1 and cox1). Imaging, including ultrasonography, computed tomography and magnetic resonance imaging, has an important role in assessing therapeutic effects earlier and more objectively.

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Drain Placement Does Not Increase Infectious Complications After Retromuscular biji klabet sebagai anti diabetic side effects Ventral Hernia Repair with Synthetic Mesh: an AHSQC Analysis. Desiccation protection by cell hydration and surface retention was assessed using cell viability assays. baumannii was associated with prior infection, invasive device utilization, prior carbapenem use and clinical severity.

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This approach is less sophisticated but identifies the areas where more sophisticated evaluation would add value. Predictors of Drug-Resistant Epilepsy in Tuberous Sclerosis Complex. Multivariate analysis was performed to determine whether the PET/CT parameters could add to the prognostic value of the Cancer of the Liver Italian Program gilead hep c drug sovaldi and olysio (CLIP) scoring system and the Barcelona-Clinic Liver Cancer (BCLC) staging system. Our results highlight the close interdependence between consumer effects, soil nutrients, and plant functional traits and suggest that plant traits may provide an improved understanding of how consumers and nutrients influence plant community productivity and diversity. The uptake pattern was unexpected for the patient with this malignancy and she had a history of rheumatoid arthritis.

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Canonical Partial Least Squares (CPLS) were used to decompose the two datasets and fuse the EEG and fMRI features. Estrogens are well known to exert antiinflammatory effects outside the central nervous system (CNS). New approaches to the treatment of patients with idiopathic mitral valve prolapse Home based oral amoxicillin treatment was equivalent to hospital treatment for first 48 h in selected children of chest indrawing pneumonia and was cheaper. To date, vapA and carbagen overdose on sleeping its positive regulators virR and orf8 are the only experimentally established virulence genes residing on the virulence plasmid.

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Standard test species may differ in their trimezol dosage response to toxicants. Illegal product diversion: the threat to the non-hospital supply market. DRG neurites were shown to contain high basal levels of activated SAPKs.

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Future interventions might target eplerenone to spironolactone dose conversion mcg feeding interaction and consider effects on infant iron status and developmental/behavioral outcomes among IDA infants, as well as infant feeding practices per se. Because most religions advocate affiliation and provide opportunities for frequent experiences of affiliation, we reasoned that religious people might show greater affiliation motivation in everyday attitudes and behaviors. Thus, we placed injections of retrograde or anterograde tracers into different IP subdivisions or the MnR and additionally examined the transmitter phenotype of major IP and MnR afferents by combining retrograde tract tracing with immunofluorescence and in situ hybridization techniques. Cardiovascular disease is a leading cause of death and disability in adults in Latin America. The etiology of genu valgum was mainly idiopathic or associated withobesity.

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the conclusion that evolutionary rate is slow enough to indicate PNC, requires a comparison with another clade, another trait or well-developed null model assumptions and thus additional data. To examine the impact of housing status on health service utilization patterns clindacin etz reviews in low-income HIV-infected adults. I describe two basic methods that can be used for either discrete or continuous environments. Diffuse intrinsic pontine glioma (DIPG) is the most severe pediatric solid tumor, with no significant improvement in the past 50 years. In addition, we suggest experimental healing of such traps according to their chemical origin and nanocrystal composition.

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Complete urethral imaging is especially important at presentation because the insertion of a transurethral bladder catheter may exacerbate an existing injury (eg, cause a partial urethral tear to become a complete transection). Co-worker support was found to have no effect on work engagement. The rehabilitation rabec 20 mg rabeprazol precio of a child after a stroke is different from that of an adult. Effects of Aquatic Intervention on Gross Motor Skills in Children with Cerebral Palsy: A Systematic Review.

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The results suggest that rapid cell-specific regulation of splice variant expression may contribute to different forms of long-term synaptic plasticity. Under these experimental conditions, the high fluoride toothpastes promoted remineralization and inhibited demineralization more effectively, than the 1450 ppm F, the non-fluoridated (control) and the calcium floxifar ciprofloxacin ophthalmic solution sodium phosphosilicate toothpastes.

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pooled analyses of time series with Poisson regression models to estimate the association between PM10 cefpodoxime proxetil tab from different sources (desert and non-desert) and different outcomes. The first phase included an anonymous, web-based cross-sectional survey administered to providers at all 24 VA SCI/D Centers. The present study was undertaken to improve the accuracy of OSE identification and to distinguish phenotypic variations of normal OSE cells from early (pre)neoplastic changes.