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Zepatier (Ribavirin)
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Ribavirin

Zepatier in combination with PEGASYS (peginterferon alfa-2a) is indicated for the treatment of patients 5 years of age and older with chronic hepatitis C (CHC) virus infection who have compensated liver disease and have not been previously treated with interferon alpha. Zepatier should be taken with food. Zepatier should be given in combination with PEGASYS; it is important to note that Zepatier should never be given as monotherapy. See PEGASYS Package Insert for all instructions regarding PEGASYS dosing and administration.

Other names for this medication:
Ribavirin, Rebetol, Copegus, Alfater, Beclabuvir, Boceprevir, Daclatasvir, Daklinza, Dasabuvir, Elbasvir, Filibuvir, Hepcinat, Hepcvir, Incivek, Kipferon, Ledifos, Ledipasvir, Miravirsen, Multiferon, Olysio, Ombitasvir, Paritaprevir, Pegasys, Pegetron, Pegintron, Rebetron, Resof, Setrobuvir, Simeprevir, Sofab, Sofovir, Sovaldi, Sylatron, Technivie, Telaprevir, Veldona, Victrelis, Viroclear, Zepatier,

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These results uncover a novel pathway that prevents over-replication of heterochromatin in Arabidopsis. Financial decisions and knowledge of health care costs were left to accountants and the bookkeeping departments in hospitals. The methods correlate the partition coefficients and dissociation constant (when appropriate) of the solute, the physical dimensions of the container, and solution pH with single parameters that dictate the shape of the sorption profile. The FAD-dependent glycerol-3-phosphate dehydrogenase of Giardia duodenalis: an unconventional enzyme that interacts with the g14-3-3 and it is a target of the antitumoral compound NBDHEX.

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The goal of this study is to identify what factors are associated with increased compliance in postoperative management of mandible fractures. Down-regulation of protein kinase Ceta potentiates the cytotoxic effects of exogenous tumor necrosis factor-related apoptosis-inducing ligand in PC-3 prostate cancer cells. In this model, endoderm-derived epithelial cells are the driving force in generating the thymic primordium, with hematopoietic cells providing later signals that organize and pattern the developing thymus. The presence of increased SRT thickness and volume on OCT, and to a lesser extent increased neurosensory retinal thickness and volume, is associated with decreased visual acuity in neovascular AMD.

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Doxorubicin in combination with a small TGFbeta inhibitor: a potential novel therapy for metastatic breast cancer in mouse models. Recently, lung volume reduction surgery (LVRS) has re-emerged in the management of emphysema with excellent results. Unstructured, tape recorded interviews were conducted to collect data.

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In the present time an accurate and effective busulfan plasma level monitoring combined with dose adjustment based on the known pharmacological parameters may improve the clinical outcome for patients undergoing BMT. This suggests that the induction of Fos provoked by oxotremorine does not involve dopamine, glutamate or opiates. treatment by community psychotherapists for borderline personality disorder: randomised controlled trial. The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy. Culture with increasing rAMH concentrations caused downregulation of its own, as well as other hormone receptors, and a decreased ovarian cortex cell proliferation.

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Consistent with the role of KMT2B in gene-activation DNA microarray analysis revealed that 152 genes were downregulated in the hippocampal dentate gyrus region of mice lacking kmt2b. Design, synthesis, and biological evaluation of novel 7-deazapurine nucleoside derivatives as potential anti-dengue virus agents. PEM tomography (PEMT) was compared with stationary PEM for point source and compressed breast phantom studies performed with a compact dual detector system. Vehicles included: all-terrain vehicles (ATV), dirt bikes, utility-terrain vehicles (UTV), golf carts, go-karts, and dune buggies. Motor perseverations: a function of the side and the site of a cerebral lesion.

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To study the relation of cytochrome C release from mitochondria to cytosol and neuronal apoptosis after cerebral hypoxia-ischemia (HI) in neonatal rats. Does the longus colli have an effect on cervical vertigo?: A retrospective study of 116 patients. Statewide teaching and research initiatives and accelerated campus-level capital development challenge the planners to create an IAIMS plan that anticipates an emerging health science environment.

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The resultant materials increase the power conversion efficiency due to light-scattering capability of submicrometer-sized particles. TWIST interacts with endothelin-1/endothelin A receptor signaling in osteosarcoma cell survival against cisplatin. The abundance, diversity, and distribution of native populations and inoculant strains in agricultural fields have been characterized using a variety of methods. Models of contagion arise broadly in both the biological and the social sciences, with applications ranging from the transmission of infectious diseases to the spread of cultural fads.

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Moreover, the Rb atoms are characterized by strong hybridization between 4d orbitals of Rb and 2p orbitals of N in C2/m structure. An electrophysiologic study did not show atrio-ventricular conduction abnormalities, so we suspected a possible sleep apnea syndrome, which was confirmed with a polysomnographic study.

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A firm diagnosis can readily be made using TRUS and the local extent of varices clearly mapped out. We show that a simple metallic diaphragm at the bending corner with properly devised sub-wavelength defect apertures of C-slits would be readily to turn on the transmissions with scarce reflections of the propagating modes, while preserving the integrity of the transmitting fields soon after the bends.

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Our genome-wide exploration identified suggestive evidence of PAD association at the OSBPL10 locus. pipiens form molestus and hybrids of the two forms did not differ between habitat categories. Self-report measures of impulsivity consistently support the notion of higher impulsive traits in BPD patients as compared to healthy control subjects. Velocity field measurement in gas-liquid metal two-phase flow with use of PIV and neutron radiography techniques.

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Covering Undocumented Immigrants - State Innovation in California. In addition to effectiveness in blood replacement, the economic benefits of the Cell Saver have not been evaluated. Reconstituted human high density lipoprotein appears to be useful in inhibiting the physiologic effects and cytokine release associated with endotoxemia and may provide adjunctive treatment for patients with gram-negative sepsis. Prevalence of norovirus infection in children and adults with acute gastroenteritis, Tehran, Iran, 2008-2009. Thirteen studies, seven with statistically significant results, were included in the review.

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In this study, the three surface treatments used improved the bond strength of resin cement to Turkom-Cera disks. Cells that were engineered to express Wnt-4 not only induced tubulogenesis in the kidney mesenchyme of Wnt-4 mutant embryos, but also induced tubules in the wild type mesenchyme.

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Focal Dermal Hypoplasia (Goltz Syndrome): A Cross-sectional Study from Eastern India. The dislocation of the hip is a secondary process, due to the influence of permanently deteriorating muscle dysbalances that first cause a decentration and finally result in a complete dislocation. Perhaps the ecologically fit fusiform rust pathogen will have additional instructions for us in the future, but for now resistance is an effective management strategy. These findings suggested that PSD-95 and nNOS may collectively participate in the proliferation of SCs, providing further evidence for the role of NO during peripheral nerve regeneration.

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Lipid droplets (LDs) store metabolic energy and membrane lipid precursors. Treatment with the AMPK inhibitor Compound C at stroke onset significantly reduced infarct size and neurological deficits 24h after stroke in ovariectomized female mice. Evaluation of microchip capillary electrophoresis with external contactless conductivity detection for the determination of major inorganic ions and lithium in serum and urine samples. Continuous electroencephalography (cEEG) monitoring is becoming increasingly used in neurologic and non-neurologic intensive care units (ICUs).

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We included patients starting first-line combination ART (cART) with or switching from first-line cART without treatment failure to tenofovir/emtricitabine, abacavir/lamivudine, tenofovir/lamivudine and zidovudine/lamivudine plus efavirenz or nevirapine. The chance of a multiple onset of thrombosis in the superficial and deep circulation represents anyway an hypothesis worth of studying. The role of pre-hospital blood gas analysis in trauma resuscitation.

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Increased expression of magnocellular arginine vasopressin mRNA in paraventricular nucleus of stress-induced depression-model rats. The main differential diagnosis of epilepsy among young adults is psychogenic non-epileptic seizures.

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Late results of treatment of toxic goiter with radioactive iodine p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors. Western compared with non-Western participants had higher knowledge-scores and better understanding of test-results. The susceptibility to the insecticide abamectin was evaluated at different times of the year on C.

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The observed increase in ventilation and inspiratory drive may contribute to the improved activity level reported by parents of PWS children during growth hormone therapy. Previous knee surgery, player position, and body mass index (BMI) may be associated with knee OA. If the formation of toxic metabolites represents a crucial bioactivation step, the found inverse conversion rates of PAs compared to the known susceptibility require further investigation. In vitro susceptibility of Blastocystis hominis isolated from patients with irritable bowel syndrome. It is also notable that MRCP techniques can be used to obtain physiological/dynamic information that ERCP cannot provide.

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A high-energy ion tail was observed, and the effective tail temperature was determined by a balance between the wave acceleration and the electron-drag relaxation. The professionalising of breast feeding--where are we a decade on? Furthermore, due to the limited number of included studies, we were unable to undertake formal meta-analyses.

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Lateral cyst of the prostate causing urinary retention and subileus. Patellofemoral joint deterioration (PFJD) is frequently seen in physical therapy clinics and represents a significant problem for both patients and rehabilitation clinicians. To date, most research has focused on the hypocrealean genera Beauveria bassiana, which is a typical filamentous fungus with a high potential for insect control. In this approach, we infer the cellular functions affected by candidate drugs by comparing morphologic changes induced by the compounds with the phenotypes of yeast mutants.

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Here we present an updated overview on the pharmacophysiologic mechanisms with special emphasis on methodologic pitfalls and possible future developments or requirements. TC substantially changed the structure of the microbial community regardless of oxygen conditions. Prostasin, a trypsin-like serine protease, is a channel-activating protease and major regulator of epithelial sodium channel-mediated sodium absorption. A variety of healthcare facilities, including hospitals, general practices, pharmacies, military hospitals, aged care facilities, mental health and other healthcare contexts.

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Addition of TCE and growth substrate in the eluent resulted in prolonged survival of PR1 and apparent mineralization of TCE. The methodology can be applied to many brain regions, providing for integrative studies of behavior and nervous system structure and function. Overall, it has been well documented that Moringa Oleifera leaves are a good strategic for various conditions associated with heart disease, diabetes, cancer and fatty liver. However, the sex ratio of beetles caught in these traps did not differ from that of control traps, and it is possible that other components may be involved in the sex pheromone signal. The latest changes include the introduction of incentive payments by the government to community pharmacists to dispense generic medicines instead of more expensive brand equivalents.

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PTX-ALG nanoparticles were first synthesized by nanoemulsification polymer cross-linking methods that improved the aqueous solubility. A heart-shaped abnormality of the cranial vault should prompt more detailed examination for other supportive features of this rare condition. The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity. HDT-1, a new synthetic compound, inhibits glutamate release in rat cerebral cortex nerve terminals (synaptosomes).

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In a cross-over, double-blinded randomized study we tested whether 2-week periods of 5, 25 or 50 Hz TENS applied to wrist flexor muscles, improved the score of the Fahn-Tolosa-Marin scale of nine patients with PWT. Increased p53 was also observed in TSC2 heterozygous and homozygous mutant human stem cells, suggesting that the interactions between TSC2 and p53 are consistent across cell types and gene dosage.

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The surgical treatment of BPH often leads to retrograde ejaculation while medical treatment leads to anejaculation. The concentration of peptides correlated with the composition of proteins in the serum. A potential early physiological marker for CNS oxygen toxicity: hyperoxic hyperpnea precedes seizure in unanesthetized rats breathing hyperbaric oxygen. Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) as a Cognitive Evaluation Tool for Patients with Normal Pressure Hydrocephalus.

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At this dose, the optic nerve showed few focal sites of axon atrophy and capillary loss. Consensus recommendations on advancing the standard of care for treating neuropathic foot ulcers in patients with diabetes. At Day 19 of gestation, expression of EMMPRIN mRNA on luminal epithelium was decreased than that observed at middle of estrous cycle, however, on Day 30 of gestation, slightly increased expression was found at the site of placentation. A number of demonstrated and potential pharmacokinetic drug-drug interactions (DDIs) exist between commonly used immunosuppressants and antidiabetic drugs, which are comprehensively summarized in this review. In a feedback mechanism, neutrophil elastase inhibits neutrophil stimulation and concomitant elastase release by cleavage of immunoglobulins, complement components, and complement receptor type 1 on neutrophils.

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The proposed triboelectric nanogenerator creates electricity by contact-separation-based electrification between an anodic metal and a cathodic polymer. For each regression model, the best exploratory covariates were determined using receiver operating characteristic (ROC) curves. Precipitation with KCl improves the chemical cross-linking of GST-fusion proteins to agarose after solubilization with SDS.

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In vivo regeneration of renal vessels post whole decellularized kidneys transplantation. To develop automated classification methods for eligibility criteria in ClinicalTrials.gov to facilitate patient-trial matching for specific populations such as persons living with HIV or pregnant women.

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The aim of this systematic review was to appraise the foot-specific PROMs available for the assessment and/or evaluation of the foot affected with rheumatoid arthritis. Mutant IcsA proteins were expressed in both smooth lipopolysaccharide (S-LPS) and rough LPS (R-LPS) S. This study aimed to assess in-hospital mortality stratified by CR training status after adjusting for surgeon and hospital volume. To evaluate the effects of surgical tape application to an incised wound after suture removal, a test using Micropore and Blenderm tape (3M, St.

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An in vitro study of symmetrical, asymmetrical, and custom asymmetrical designs. The association of pineal gland volume and body mass in obese and normal weight individuals: a pilot study.

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Interactions between these two RNAs are predicted to block the traJ ribosomal binding site. An Evaluation of the Effect of Therapeutic Ultrasound on Healing of Mandibular Fracture. Cell cycle activation in hepatocarcinogenesis can be directly triggered by overexpression of single and combinations of genes or be initiated indirectly by compensatory proliferation in response to liver injury.

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They were identified by spectroscopic methods as penta-O-galloyl-beta-glucoside (1), pedunculagin (2), 2, 3-(S)-hexahydroxydiphenoyl-D-glucose (3), tellimagrandin II (4), 2, 6-di-O-galloyl-D-glucose (5), casuariin (6), and 5-desgalloylstachyurin (7). Clinical observations and in vivo experiments suggest that T3 are involved in the suppression of herpes virus replication. Aberrant regulation of microRNAs (miRNAs) expression has been implicated in several malignancies.

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GABAA receptors are chloride channels opened by GABA whose presence in the rat superior cervical ganglion has been indicated by functional and binding measurements. FSRT provides high rates of LC for patients with brain metastases. As the evidence continues to shape our field, we hope to serve our otolaryngology community through this invited series, which is dedicated to the exposition of evidence-based medicine and its applications.

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In old rats, growth hormone administration did not significantly change growth hormone-releasing hormone and somatostatin gene expression. Microcomputed tomography and histological analyses were used to evaluate bone formation. Gap junctions between VSMCs, gap junctional communication, and Cx43 phosphorylation at Ser262 play important roles in the vascular effects of AVP. Here, we analyze the navigability of real networks by using greedy routing in hyperbolic space, where the nodes are subject to a stochastic activation-inactivation dynamics. Genotyping and Prevalence of Pyrazinamide- and Moxifloxacin-Resistant Tuberculosis in China, 2000 to 2010.

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The first article, published in the fall 1998 issue of Ambulatory Outreach, provided a framework for making the decision to invest in a freestanding ambulatory care center. Role of computerized tomography in the diagnosis of pulmonary cancer It is unclear how immune activation is involved in the psychopathology.

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Additionally, this assessment sought to evaluate the effectiveness and safety of a HEART protocol in the first 4 months after its adoption. But in the case of a cyclic temperature change of 32-36 degrees C with a stimulation cycle of 2 h, nitrite oxidization declined. Clinical neurophysiology and quantitative sensory testing in the investigation of orofacial pain and sensory function. An understanding of the racial differences is essential while designing implants for the Indian population.

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Strengthening vitality is particularly important for mid-career faculty, who represent the largest and most dissatisfied segment. We conducted a survey of journal club directors at the nine Canadian medical schools known to conduct education journal clubs. Herein, we summarize our experience with placement of transnasal drainage catheters and covered esophageal stents for the treatment of this condition.

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Import, targeting, and processing of a plant polyphenol oxidase. Again, this analysis revealed the significant expression of umbrella-specific markers in CIS when compared to non-CIS lesions. This information may be useful to patients making treatment decisions for early stage prostate cancer.

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The upgrading of the nursing education to degree level, continuous professional development, mentoring and role modeling of expert nurses should be established to prepare local nurses for the localization of the nursing workforce. High-speed cytosols were prepared from liver, thymus and uterus and incubated with the synthetic estrogen 3H-moxestrol (NEN). We report here a novel mutation in the codon for amino acid 263 resulting in the change from arginine to glutamine in the pyruvate dehydrogenase (PDH) E1 alpha gene, in two boys with primary lactic acidaemia, from independent families. Our findings suggest a novel mode of A20 action that involves lysosomal targeting of signal molecules bound to A20. Insight into the role of HSPG in the cellular uptake of apolipoprotein E-derived peptide micelles and liposomes.

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We isolated two novel actin filament (F-actin)-binding proteins from rat brain and rat 3Y1 fibroblast. The impact of bottlenecks on microbial survival, adaptation, and phenotypic switching in host-pathogen interactions. The enzyme has been purified to apparent homogeneity and shown to possess the characteristic ATP-dependent proteolytic activity. The results lead us to conclude that under the stated conditions the product has little embryotoxicity.

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Total-body radiation suppression of the clearance of phenylalanine ammonia-lyase from mouse plasma. In this randomised within-patient controlled pilot trial, 20 patients with hypertrophic CMs will be enrolled.

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There was a marked increase of the sensory neuropeptide neurokinin A and the sympathetic related transmitter neuropeptide Y in hindpaw perfusates after scalding. Serum creatine kinase activity and serum creatine kinase isoenzymes in newborn infants. Finally, we show how the progression of understanding the role of lanthionine synthetase C-like 2 has encompassed both nutritional and therapeutic advances and led to the development of novel oral small molecule therapeutics for IBD. We tested this hypothesis in Japanese beetles (Popillia japonica Newman), a pest clovate clobetasol ointment species in which males and females may be either isolated or in aggregations while feeding on host plants.

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Numerous comparative studies have demonstrated the advantages uroxatral side effects insomnia treatment of the increased relaxivity in terms of enhanced image contrast, image quality and diagnostic confidence. Resveratrol restores the antinociceptive effect of morphine by reversing morphine infusion-induced spinal cord neuroinflammation and increase in TNFR1 expression. To evaluate the associations between breastfeeding duration, age at solids introduction, and their interaction in relation to infant (age 9-15 months) above normal body mass index (BMI).

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Although McCune-Albright syndrome isa rare clinical entity, it should be considered as a possible differential mode of action of metronidazole drug class diagnosis of bone metastasis in patients with breast cancer. An immunofluorescence procedure for the detection of intracellular immunoglobulins. Moreover, this biochip format could be modified to extend to the screening scope of SNPs for any other human mitochondrial diseases. The majority of degenerating spino-olivary terminals underwent an electrondense change.

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Examine: (1) the anthropometric, socio-demographic and use-of-time characteristics of thin adolescents, and (2) compare these characteristics to other weight status categories. Compounds 2, 3, and 6 phosphorylate AMPK (AMP-activated protein kinase), and resulted in increased phosphorylation of GSK-3beta and suppression of lipogenic expression (ACC and FAS) in a dose-dependent manner. Thus, WHR or WC may be better indicators for assessing hormonal patterns implicated in breast cancer pathogenesis in these women. Since individual leaf tissues have specialized functions, their protein composition is different and hence also protein level regulation is expected to differ. Functional CT uses Patlak analysis of a single location dynamic sequence to extract germentin 250mg is how many ml physiological information that is useful clinically i the assessment of cerebral gliomas.

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Gel shift assays and footprinting experiments indicate that HMBP binding overlaps two of these methylated Sp1 sites. In particular, the influence of protein-enriched diets on the hypothalamus is comparable to the activation observed after glucose infusion into the portal vein. Preparation and characterization auram 3000 for sale of carbon nanotubes/chitosan composite foam with enhanced elastic property.